The HPV type 1 causes most plantar warts. The virus gains access to the skin through direct contact. It is presumed that inoculation of the skin probably occurs in places likely to be contaminated by others with plantar warts, like communal showers. There are a variety of innate mechanisms that seem to be important in resisting infections. Once infected by HPV, spontaneous resolution seems to depend on the development of immune lymphocytes that destroy the virus-infected cells. It appears that the levels of neutralizing antibodies in the blood induced by vaccination with HPV proteins can protect against certain types of infections.
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